In January 2010, Rayados became InterLiga champions, allowing them to return to Copa Libertadores.
The double competition and the long trips affected the team, so it did not perform well in the South American competition.
However, despite the absence of Humberto Suazo, who emigrated to Zaragoza in Spain, Rayados defended the Liga MX title in the Bicentenario 2010 with high-quality soccer.
The team finished as the overall leader, losing only one game in the entire season, but only made it as far as the Quarterfinals.
In the 2010 Apertura, with Suazo back, the team ended up as the overall runner-up. In the playoffs, Rayados defeated Pachuca. In the Semifinals, they beat Pumas. In the Final, Monterrey faced Santos Laguna.
In the first leg, Los Laguneros won 3-2, but in the second leg, played at the Estadio Tecnológico, Rayados were clearly superior and won 3-0 with a brace from Suazo and antoher goal from Jose María Basanta.
Rayados won their fourth league title, the second one in less than a year!
In 2011, Rayados began a golden era in the international arena.
After an undefeated run through the group stage of the CONCACAF Champions League, Rayados left Toluca and Cruz Azul in their wake to reach the Final, where they faced Real Salt Lake of the MLS.
Monterrey tied 2-2 at Tecnológico, so they had to go to Utah for the win.
On April 27, 2011, Humberto Suazo scored a brilliant goal for Rayados to beat Real Salt Lake 1-0 and win their first CONCACAF Champions League title.
This title earned them a place in their first Club World Cup, which was held in Japan in 2011.
In 2012, Rayados continued to write his international history by reaching its second CONCACAF Champions League Final.
On April 18, 2012, in the first leg against Santos at the Tecnológico, Humberto Suazo scored both goals for a 2-0 win.
The second leg game was played in Torreón on April 25, 2012. Santos managed to tie the aggregate score 2-2, but with nine minutes remaining in regulation time, Neri Cardozo scored the goal that would give Monterrey the two-time championship and a place in the 2012 Club World Cup in Japan.
In the Liga MX, Vucetich's Monterrey finished as overall runner-up in the 2012 Clausura and reached the Final, where they faced Santos again. However, this time they finished as runner-up.
In the 2012 Japan Club World Cup, Rayados defeated South Korea's Ulsan Hyundai in the quarterfinals. In the Semifinal, they faced the powerful Chelsea, reigning champion of the UEFA Champions League. Rayados were unable to pull off the surprise of beating the English team and few days later managed to take third place in the competition.
In 2013, still coached by Vucetich, Rayados achieved the feat of winning the CONCACAF Champions League for the third time, after beating Santos once again.
This time, the first leg game was played in Torreón, where it ended in a 0-0 draw. The return leg took place on May 1, 2013 at the Estadio Tecnológico.
The outlook seemed bleak for Monterrey. In the 50th minute they were 2-0 down and, since the away goal was the first tie-breaker, they were obliged to score 3 goals and not concede any.
Between the 59th minute and the 90th minute, Rayados pulled off a feat by scoring not just 3, but 4 goals, two by Aldo De Nigris, one by Neri Cardozo and another by Humberto Suazo.
That historic comeback gave Rayados the CONCACAF Champions League title three times in one of the most exciting nights in the Club's history.
Rayados attended its third Club World Cup in December 2013, now under the command of José Guadalupe Cruz.
In 2014, the team began a process of sports reconstruction. The heroes of previous years were leaving the Institution. The Apertura 2014 was also the last tournament for striker Humberto Suazo, who left the Club with 121 goals scored with Rayados.
In the Clausura 2015, Rayados said goodbye to their old house, the Estadio Tecnológico. In the last match, Monterrey tied 2-2 against Pumas. With his goal, Dorlan Pabon became the Club's fourth goal scoring champion and Jesús Zavala, the last player to score in this venue.
One of the greatest dreams in the history of the Club and its fans came true in August 2015, when Rayados inaugurated their new home: the Estadio BBVA.